An improved synthesis of N4-aminocytidine.

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Mutagenic nucleoside analog N4-aminocytidine: metabolism, incorporation into DNA, and mutagenesis in Escherichia coli.

N4-Aminocytidine, a nucleoside analog, is strongly mutagenic to various organisms including Escherichia coli. Using E. coli WP2 (trp), we measured the incorporation of [5-3H]N4-aminocytidine into DNA and at the same time measured the frequency of reversion of the wild type, thereby attempting to correlate the incorporation with mutation induction. First, we observed that N4-aminocytidine uptake...

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ژورنال

عنوان ژورنال: Chemical and Pharmaceutical Bulletin

سال: 1987

ISSN: 0009-2363,1347-5223

DOI: 10.1248/cpb.35.3884